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US 8,507,710 B2Granted
Use of perifosine in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
AssigneeAEterna Zentaris GmbH
InventorsJurgen Engel, Eckhard Gunther, Herbert Sindermann
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Abstract
The invention relates to pharmaceutical compositions comprising alkylphosphocholines and antimetabolite antitumor substances. The pharmaceutical compositions of the invention are useful for the treatment of benign and malignant oncoses in humans and animals. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.
Claims6
A pharmaceutical composition for the treatment of benign or malignant oncoses, said composition comprising:
- (a) perifosine;
- (b) at least one antimetabolite antitumor substancselected from group consisting of 5-fluorouracil, cytarabine, and gemcitabine;
- and
- (c) optionally, customary pharmaceutical carriers, excipients, and/or diluents.
1 more element
Dependencies are inferred from the claim text.