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US 8,507,698 B2Granted
Artemisinin derivatives for the treatment of melanoma
AssigneeLachifarma S.R.L. Laboratorio Chimico Farmaceutico Salentino
InventorsLuigi Villanova, Azzurra Villanova, Luciano Villanova
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Abstract
The invention relates to Artemisinin derivatives of general formula (I) wherein A and B are as defined in the specification. Compounds (I) have proved able to inhibit cell proliferation, in particular of uveal melanoma cells, and can therefore be used, either alone or in association with other antitumoral drugs, for the preparation of medicaments intended for the treatment of malignant melanoma.
Claims8
A compound of general formula (I)
- wherein,
- A represents a —(CH2)n— group wherein n is an integer between 1 and 6, and
- B represents a group of formula
- wherein R1 and R2 independently represent hydrogen, hydroxy, C1-C5 alkoxy, straight-chain or branched, an aryloxy group, or phenoxy,
- excluding the compound of formula:
2 more elements
A compound of formula (I)
- wherein:
- A represents a 5- or 6- member carbocyclic ring, optionally containing one or more heteroatoms selected from N, O and S, and
- B represents an OH group.
Dependencies are inferred from the claim text.