Intermediates in the synthesis zearalenone macrolide analogs

A crystalline intermediate of formula (VII):

• wherein R1 and R2 are each independently selected from the group consisting of hydrogen, and C1-6 alkyl;
• R3 is selected from benzoyl or benzyl, wherein the benzoyl or benzyl are each substituted with 0, 1, 2 or 3 substituents independently selected from —OH, —O(C1-4alkyl), —NH2, —NH(C1-4-alkyl), —N(C1-4-alkyl)2, amides, —OCO(C1-4-alkyl) and (C1-4-alkyl);
• R5 and R6 are each independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, phenyl and benzyl, wherein the phenyl or benzyl are substituted with 0, 1, 2, or 3 substituents independently selected from halogen, hydroxyl, C1-3 alkyl, and NH2;
• or R5 and R6 are taken together with the carbons on which they are attached to form a 5-6 unconjugated membered carbocyclic ring;
• R11 and R12 are each independently selected from the group consisting of hydrogen and a base stable oxygen protecting group;
• or R11 and R12 are taken together to form a 5 membered heterocyclyldiyl of structure (a):
• wherein R19 and R20 are each independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and phenyl, or R19 and R20 together represent a fluorenyl moiety of structure (b):
• and
• R13 is
• wherein
• R14, R15, R16, R17, and R18 are each independently selected from the group consisting of H, NO2, —NH3+, —COH, —CO(C1-4 alkyl), —COCl, —COOH, —COO(C1-4 alkyl), —NR3+, —SO3H, nitrile, —CF3 and halogen, wherein at least one of R14, R15, R16, R17, and R18 is selected from the group consisting of NO2—NH3+, —COH, —CO(C1-4 alkyl), —COCl, —COOH, —COO(C1-4 alkyl), —NR3+, —SO3H, nitrile, —CF3 and halogen and the other of R14, R15, R16, R17 and R18 are hydrogen.