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US 8,507,694 B2Granted
Process for the preparation of pyrazole carboxylic acid amides
AssigneeSyngenta Crop Protection AG
InventorsDenis Gribkov, Adrian Müller, Martin Lager, Fanny Giordano
Life of this patent
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Abstract
The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide.
Claims8
A process for the preparation of the compound of formula I
- which process comprises
- a) reacting the compound of formula II
- in the presence of a catalyst in a suitable organic solvent with the compound of formula III
- to the compound of formula IV
- b) hydrogenating the compound of formula IV in the presence of a metal catalyst to the compound of formula V
- c) reducing the compound of formula V in the presence of a reducing agent to the compound of formula VI
- d) dehydrating the compound of formula VI in the presence of an acid to the compound of formula VII
- e) reacting the compound of formula VII with hydroxylamine to the compound of formula VIII
- and
- f) acylating the oxime oxygen of the compound of formula VIII in the presence of a solvent and an acylating agent and finally reacting the obtained product with the compound of formula IX
- or
- ff) reacting the compound of formula VIII with an excess of the compound of formula IX.
9 more elements
The compound of formula IV
- and its stereoisomers.
The compound of formula V
- and its stereoisomers.
The compound of formula VI
- and its stereoisomers.
The compound of formula VII
- and its stereoisomers.
The compound of formula VIII
- and its stereoisomers.
Dependencies are inferred from the claim text.