Thiazole derivative and use thereof as VAP-1 inhibitor

A compound represented by the formula (I):

• R1—NH—X-J-L-M-A-B-D-E
• wherein
• R1 is acyl;
• X is a divalent optionally substituted thiazole;
• J is a bond, lower alkylene, lower alkenylene, lower alkynylene, or —(CH2)n—CO—, where n is 0;
• L is a bond, —O—, —NH—, —CO— or —SO2—;
• M is a bond, lower alkylene, lower alkenylene or lower alkynylene,
• A is a divalent optionally substituted benzene, or a divalent optionally substituted thiophene;
• B is —(CH2)l—NR2—CO— wherein R2 is hydrogen, lower alkyl or acyl, and l is an integer of 1 to 6, —(CH2)m—O—CO— or —(CH2)m—S—CO— wherein m is an integer of 0 to 6;
• D is —NR3— wherein R3 is hydrogen, lower alkyl, alkoxycarbonyl or acyl;
• and
• E is optionally substituted amino;
• or a pharmaceutically acceptable salt thereof.