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US 8,507,683 B2Granted
Compounds for the treatment of hepatitis C
AssigneeBristol-Myers Squibb Company
InventorsKap-Sun Yeung, John F. Kadow, Rajesh Onkardas Bora, Kumaravel Selvakumar
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Abstract
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Claims6
A compound of formula I
- where:
- R1 is phenyl or pyridinyl and is substituted with 0-3 substituents selected from the group consisting of halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkoxy, hydroxyalkyloxy, and alkoxyalkyloxy, and is also substituted with 1 CON(R9)(R10) substituent;
- R2 is hydrogen, halo, or alkyl;
- R3 is CONHCH3;
- R4 is phenyl that is independently substituted with 0-2 halo or methoxy or is para substituted with X—Ar1;
- R5 and R6 are independently hydrogen, alkyl, halo, N(R7)(R8), or alkylsulfonyl;
- R7 and R8 are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, alkylsulfonyl, or alkylsulfonylalkyl;
- or N(R7)(R8) taken together is azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, and is substituted with 0-2 substituents selected from alkyl, hydroxyalkyl, or hydroxy;
- R9 is hydrogen;
- R10 is
- R11 and R12 taken together is —CH2OCH2—, —OCH2CH2—, —CH2OCH2CH2—, —OCH2CH2CH2—, —OCH2CH2CH2CH2—, —CH2OCH2CH2CH2—, —CH2CH2OCH2CH2— (thus forming an oxetanyl, dihydrofuranyl, or dihydropyranyl ring);
- X is —O— or —NH—;
- Ar1 is phenyl or para-halophenyl;
- and
- Ar2 is phenyl, pyridinyl, pyrazolyl, isoxazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, oxadiathiazolyl, triazolyl, tetrazolyl, pyrazinyl, or pyrimidinyl, and is substituted with 0-3 substituents selected from halo, alkyl, or dialkylamino;
- or a pharmaceutically acceptable salt thereof.
13 more elements
Dependencies are inferred from the claim text.