Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds

A process for preparing compounds of Formula I:

• or salts thereof,
• wherein
• R1 is H, halo, alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, amino;
• R2 is alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, amino;
• R3 is H, alkyl, aryl, cycloalkyl;
• R4 is alkyl, alkenyl, aryl, arylalkyl, arylalkenyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl;
• comprising:
• (a) reacting a compound of Formula II:
• wherein
• R8 is C1-8 alkyl, C6-14 aryl, C7-20 arylalkyl, C4-7 heterocyclic, C5-15 heterocyclicalkyl, C4-7 heteroaryl, C5-15 heteroaralkyl, C1-8 alkoxy, C6-14 aryloxy, C7-20 arylalkoxy, C4-7 heterocyclicoxy, C5-15 heterocyclicalkoxy, C4-7 heteroaryloxy, or C5-15 heteroaralkyloxy;
• X is F, Cl, Br, or I;
• R1 is as defined above;
• and
• R2 is as defined above and is, optionally, protected with a protecting group;
• with a compound of Formula III:
• R3R4NH Formula III
• wherein
• R3 is as defined above and is, optionally, protected with a protecting group;
• R4 is as defined above and is, optionally, protected with a protecting group;
• in a solvent system comprising water and one or more organic solvents, optionally in the presence of a base;
• and
• (b) deprotecting the resulting compound to produce a compound of Formula I or a salt thereof;
• wherein each alkyl group may be optionally substituted by one or more halo, alkyl, lower alkyl, alkenyl, cycloalkyl, acyl, hydroxy, hydroxyalkyl, heterocyclic, heteroaryl, aryl, amino, aminoalkyl, —NRxRy, oxo, cyano, carboxy, carboxyalkyl, alkoxycarbonyl, —ORx, —C(O)Rx, —C(O)—NH2, —C(O)—N(H)Rx, —C(O)—N(H)O Rx, —C(O)—NRxRy, —NRyC(O)Rx, —NRyC(O)NRxRy, —OC(O)NRxRy, —NRyC(O)ORx, —S(O)n—Rx, —S(O)2—NH2, —S(O)n—N(H)Rx and/or —S(O)2—NRxRy, wherein Rx and Ry are each independently C1-6 alkyl.