Back to results
US 8,507,668 B2Granted
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AssigneeLes Laboratoires Servier
InventorsJean-Luc Renaud, Nicolas Pannetier, Sylvain Gaillard, Jean-Pierre Lecouve, Lucile Vaysse-Ludot
Life of this patent
Estimating the term…
Abstract
Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
Claims5
A process for the synthesis of ivabradine of formula (I):
- wherein a compound of formula (V):
- is subjected to a reductive amination reaction with an amine of formula (VI):
- in the presence of formic acid in an amount greater than 1 equivalent per equivalent of aldehyde
- and of triethylamine in an amount greater than 1 equivalent per equivalent of aldehyde,
- at a temperature from 15 to 100° C.,
- in the absence of solvent or in an alcoholic solvent.
3 more elements
Dependencies are inferred from the claim text.