Compositions and methods for inhibiting expression of CD274/PD-L1 gene
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsAntonin Defougerolles, Tatiana Novobrantseva, Brian Bettencourt
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Abstract
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
Claims16
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of CD274/PD-L1, wherein said dsRNA comprises a sense strand and an antisense strand, wherein the sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:
- 415 and the antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the corresponding antisense nucleotide sequence of SEQ ID NO:
- 416, and wherein each said strand is no more than 30 nucleotides in length.
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of CD274/PD-L1, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a CD274/PD-L1 RNA transcript, which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the antisense sequence of SEQ ID NO:
- 416, and wherein each said strand is no more than 30 nucleotides in length.
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of CD274/PD-L1, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a CD274/PD-L1 RNA transcript, which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the antisense sequence consisting of SEQ ID NO:
- 416 and wherein the sense strand consists of SEQ ID NO:
- 415.
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of CD274/PD-L1, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a CD274/PD-L1 RNA transcript, which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the antisense sequence consisting of SEQ ID NO:
- 416 and wherein the dsRNA comprises a sense strand consisting of a sense strand sequence of SEQ ID NO:
- 415.
Dependencies are inferred from the claim text.