Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
AssigneeStichting Dienst Landbouwkundig Onderzoek
InventorsFlorine Johanna van Milligen, Johannes Bernardus Wilhelmus Joseph Cornelissen, Bernard Adri Bokhout
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Abstract
Described are antibodies specifically directed against a cathepsin-like protease that are specific for newly excysted juvenile (NEJ) stages of Fasciola hepatica. Diagnostic tests wherein such antibodies are detected or used are also provided.
Claims13
An isolated or synthetic antibody specifically directed against a proregion of a cathepsin-like protease obtained from excretory/secretory products of newly excysted juvenile (NEJ) stages of Fasciola hepatica, wherein the proregion consists of a peptide comprising the amino acid sequence SEQ ID NO:1, an amino acid sequence consisting of at least 85% sequence identity with SEQ ID NO:
- 24, or an amino acid sequence consisting of at least 85% sequence identity with SEQ ID NO:
- 26.
Dependencies are inferred from the claim text.