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US 8,507,656 B2Granted
Stabilized angiopoietin-2 antibodies and uses thereof
AssigneeMedImmune, LLC
InventorsVahe Bedian, William Dall'Acqua, Herren Wu, Michael Bowen, Jeffrey Brown, Chris Stannard, Ralph Minter, Andrew Buchanan
Life of this patent
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Abstract
Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.
Claims15
An isolated antibody that binds to angiopoietin-2 (Ang-2), wherein the antibody comprises a heavy chain variable region of SEQ ID No:7 (MEDI5) and a light chain variable region selected from the group consisting of:
- a) SEQ ID No:3 (MEDI1);
- b) SEQ ID No:4 (MEDI2);
- c) SEQ ID No:5 (MEDI3);
- d) SEQ ID No:6 (MEDI4);
- and
- e) SEQ ID No:8 (MEDI6).
3 more elements
A pharmaceutical composition comprising:
- a) an excipient;
- and
- b) an isolated antibody that binds to Ang-2, wherein the antibody comprises a heavy chain variable region of SEQ ID No:7 (MEDI5) and a light chain variable region selected from the group consisting of:
- i) SEQ ID No:3 (MEDI1);
- ii) SEQ ID No:4 (MEDI2);
- iii) SEQ ID No:5 (MEDI3);
- iv) SEQ ID No:6 (MEDI4);
- and
- v) SEQ ID No:8 (MEDI6).
6 more elements
Dependencies are inferred from the claim text.