Altered antibodies
AssigneeUCB Pharma S.A.
InventorsTerence Seward Baker, David Paul Humphreys, Alastair David Griffiths Lawson
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Abstract
This invention relates to engineering of antibodies and more specifically provides altered antibodies of the IgG class to which one or more effector molecules are attached. The invention further relates to methods for the production of such conjugated antibodies.
Claims9
An altered antibody of the class IgG comprising at least one human kappa light chain with a variable region, and at least one human heavy chain with a variable region, or an epitope-binding fragment thereof comprising said alteration, wherein the alteration comprises replacing one of residues 171, 156, 202 and 203, numbered according to the Kabat numbering system, of the at least one kappa light chain with a cysteine residue.
Dependencies are inferred from the claim text.