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US 8,507,653 B2Granted
Factor IX moiety-polymer conjugates having a releasable linkage
AssigneeNektar Therapeutics
InventorsMary J. Bossard, Gayle Stephenson
Life of this patent
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Abstract
The present invention provides Factor IX moiety-polymer conjugates having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Claims15
A compound having the following structure:
- wherein:
- POLY1 is a first water-soluble polymer;
- POLY2 is a second water-soluble polymer;
- X1 is a first spacer moiety;
- X2 is a second spacer moiety;
- Hα is an ionizable hydrogen atom;
- R1 is H or an organic radical;
- R2 is H or an organic radical;
- (a) is either zero or one;
- (b) is either zero or one;
- Re1, when present, is a first electron altering group;
- Re2, when present, is a second electron altering group;
- Y1 is O or S;
- Y2 is O or S;
- and
- (F9) is a residue of an amine-containing Factor IX moiety.
13 more elements
A method comprising contacting a polymeric reagent with a Factor IX moiety comprising an amino group under conditions suitable to form a covalent attachment between the polymeric reagent and the Factor IX moiety amino group, wherein the polymeric reagent has the following structure:
- wherein:
- POLY1 is a first water-soluble polymer;
- POLY2 is a second water-soluble polymer;
- X1 is a first spacer moiety;
- X2 is a second spacer moiety;
- Hα is an ionizable hydrogen atom;
- R1 is H or an organic radical;
- R2 is H or an organic radical;
- (a) is either zero or one;
- (b) is either zero or one;
- Re1, when present, is a first electron altering group;
- Re2, when present, is a second electron altering group;
- and
- (FG) is a functional group capable of reacting with the amino group of the Factor IX moiety to form a releasable linkage.
11 more elements
Dependencies are inferred from the claim text.