Multiphasic absorbable compositions of segmented l-lactide copolymers
AssigneePoly-Med, Inc.
InventorsShalaby W Shalaby, Michael Scott Taylor, Shawn J. Peniston
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Abstract
Absorbable, multiphasic, crystalline, solid blend compositions having at least two first order thermal transitions, are formed of a segmented l-lactide copolymer as the principal or major component and at least one additional crystalline thermoplastic absorbable polyester having glycolide-based sequences, a fraction of which participated in ester-ester interchange reactions with lactide-based sequences to produce crystalline materials with modulated properties for use in producing orthopedic and tissue-repair devices.
Claims16
An absorbable, multiphasic, crystalline, solid blend composition comprising at least 45 percent by weight of a major component comprising a segmented l-lactide copolymer, at least one minor component comprising at least one additional crystalline thermoplastic absorbable polyester having glycolide-based sequences, a fraction of the glycolide sequences interchanged with a fraction of the lactide sequences of the major component, the overall composition exhibiting at least two first order thermal transitions with a peak temperature difference exceeding 10° C., the overall composition having a crystallinity of at least 10 percent of the crystallinity of the major component as measured in terms of heat of fusion (ΔHf), wherein the crystallinity decreases as the number of interchanged glycolide and lactide sequences increases;
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- wherein the composition is formed through a melt blending process that includes a controlled ester-ester interchange reaction.
Dependencies are inferred from the claim text.