Pseudo-thermosetting neutralized chitosan composition forming a hydrogel and a process for producing the same
AssigneeLaboratoire Medidom S.A.
InventorsJérôme Berger, Robert Gurny, Marianne Reist Oechslin
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Abstract
The composition disclosed is a pseudo-thermosetting neutralized chitosan composition, neutralized with a hydroxylated base, forming a phosphate-free transparent hydrogel at a temperature higher than 5° C. Said composition contains a homogeneously reacetylated chitosan derived from a chitosan having a deacetylation degree of 80-90%, having a molecular weight of not smaller than 200 kDa and a deacetylation degree of 30-60%, and may further contain a diol. Said composition may be used as a drug delivery system.
Claims7
A pseudo-thermosetting neutralized chitosan composition, which comprises 0.1 to 2.0 wt/v %, based on the total composition, of a homogeneously reacetylated chitosan derived from a chitosan having a deacetylation degree of 80-90%, and wherein the homogeneously reacetylated chitosan has an average molecular weight of not smaller than 200 kDa and a deacetylation degree of 30-60%, neutralized with an hydroxylated base, wherein said composition forms a phosphate-free transparent hydrogel at a temperature higher than 5° C.
A drug delivery system comprising a pseudo-thermosetting neutralized chitosan composition which comprises 0.1 to 2.0 wt/v %, based on the total composition, of a homogeneously reacetylated chitosan derived from a chitosan having a deacetylation degree of 80-90%, and wherein the homogenously reacetylated chitosan has an average molecular weight of not smaller than 200 kDa and a deacetylation degree of 30-60%, neutralized with an hydroxylated base, wherein said composition forms a phosphate-free transparent hydrogel at a temperature higher than 5° C.
Dependencies are inferred from the claim text.