Fatty acid treatment for cardiac patients
AssigneeBaylor Research Institute
InventorCharles R. Roe
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AssigneeBaylor Research Institute
InventorCharles R. Roe
Estimating the term…
A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial β-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.
A composition comprising a seven carbon fatty acid source in a dosage unit, wherein the dosage unit comprises at least about 15 grams of the seven carbon fatty acid source and wherein the composition is provided in an amount suitable for providing 15% to 40% of the daily dietary calories of a human, wherein the seven carbon fatty acid source is selected from the group consisting of n-heptanoic acid, a triglyceride comprising n-heptanoic acid and triheptanoin and wherein the composition does not contain long-chain or very long-chain fatty acid.
Dependencies are inferred from the claim text.