Quorum sensing antagonist and method of reducing a bacterial contamination using the quorum sensing antagonist
AssigneeSeoul National University Industry Foundation
InventorsJe-Yong Yoon, Cheol-Jin Kim, Jae-Eun Kim, Hyung-Yeon Park
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Abstract
In the quorum sensing antagonist blocking the communication in bacteria, the method for preventing biofilm formation using this quorum sensing antagonist and the method for reducing the bacterial contamination, the quorum sensing antagonist contains the homoserine lactone moiety and sulfanylethanoyl group, and has a similar chemical structure to that of the autoinducer which is produced by bacteria as a signal, whereby the quorum sensing antagonist can inhibit the formation of biofilm and reduce the bacterial contamination as well.
Claims20
A quorum-sensing antagonist comprising a molecular structure of the following formula:
- wherein n is an integer from 0 to 10, and
- wherein R1 indicates hydrogen, a carboxyl group, a nitrogen-containing hetero-aromatic hydrocarbon group, or a carboxyalkylthio group that has a carbon number from 1 to 10.
A quorum-sensing antagonist comprising a molecular structure of the following formula:
- wherein n is an integer from 0 to 10, and
- wherein R2 defines an aromatic hydrocarbon group or the carboxyalkylthio group.
Dependencies are inferred from the claim text.