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US 8,507,552 B2Granted
Triptolide prodrugs
AssigneeRegents of the University of Minnesota
InventorsIngrid Gunda Georg, Satish Prakash Patil, Ashok K. Saluja, Rohit Chugh, Selwyn M. Vickers
Life of this patent
Estimating the term…
Abstract
The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.
Claims16
A compound of formula I:
- wherein:
- each R1 is independently H, (C1-C6)alkyl, aryl(C1-C6)alkyl-, (C3-C6)cycloalkyl or aryl;
- and each R2 is independently H, (C1-C6)alkyl, aryl(C1-C6)alkyl-, (C3-C6)cycloalkyl or aryl;
- or R1 and R2 together with the atom to which they are attached form a (C3-C7)cycloalkyl;
- wherein any alkyl or cycloalkyl of R1 or R2 may be optionally substituted with one or more groups selected from halo, (C1-C6)alkoxy and NRaRb and wherein any aryl of R1 or R2 may be optionally substituted with one or more groups selected from halo, (C1-C6)alkyl, (C1-C6)alkoxy, NRaRb, nitro and cyano;
- Ra and Rb are each independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl and aryl;
- or Ra and Rb together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, azetidino, morpholino, or thiomorpholino;
- n is 1, 2 or 3;
- and
- each X is H;
- or a salt thereof.
8 more elements
Dependencies are inferred from the claim text.