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US 8,507,549 B2Granted
Methods for synthesizing glycinols, glyceollins I and II and isoflavenes and chromanes using a Wittig reaction, and compositions made therewith
AssigneeThe University of Toledo
InventorsPaul W. Erhardt, Rahul S. Khupse, Amarjit Luniwal
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Abstract
Methods for synthesizing glycinols, glyceollins I and II, and isoflavene and chromane compounds using a Wittig reaction, compositions made therewith, and uses thereof are described.
Claims4
A process for preparing 4′,7-dioxygenatedisoflav-3-ene compounds, comprising:
- converting a compound of Formula I:
- into a phosphonium salt intermediate of Formula II:
- accomplishing ring closure by an intramolecular Wittig reaction to produce a 4′,7-dioxygenated-isoflay-3-ene compound of Formula III:
- wherein R1 and R2 are either the same or independently H, alkyl, or a phenolic protecting group;
- and alkyl comprises a straight or branched alkane group having from 1 to 6 carbons.
2 more elements
Dependencies are inferred from the claim text.