Potassium channel blockers and uses thereof

A compound of formula (I) or salt thereof,

• wherein
• R1 is selected from the group consisting of hydrogen, halo, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted C3-7 cycloalkyl, —OR, —C(O)R, —C(O)OR and —OC(O)R (where R is selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl), —C(O)NR′″R″″, —NR′″C(O)R″″ and —NR′″R″″ (where R″′ and R″″ are independently selected from the group consisting of hydrogen, lower alkyl and aryl);
• R2 is selected from the group consisting of halo, cyano, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted C3-7 cycloalkyl, —OR, —C(O)R, —C(O)OR, —OC(O)R (where R is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl), —C(O)NR′″R″″, —NR′″C(O)R″″ and —NR′″R″″ (where R″′ and R″″ are independently selected from the group consisting of hydrogen, lower alkyl and aryl);
• R3 is selected from the group consisting of:
• —C(O)R6, where R6 is selected from the group consisting of lower haloalkyl, optionally substituted alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted aryl, —OR, —C(O)R, —C(O)OR, —OC(O)R, SR (where R is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl), —C(O)NR′R″, —NR′C(O)R″ and —NR′R″ (where R′ and R″ are independently selected from the group consisting of hydrogen or lower alkyl);
• —S(O)mR′″ (where m is 1 or 2 and R′″ is independently selected from the group consisting of NH2, dialkylamino, monoalkylamino, optionally substituted alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl and optionally substituted aryl);
• —SR (where R is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl);
• —C(OH)HR (where R is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl);
• optionally substituted heterocyclyl;
• optionally substituted heteroaryl;
• NR′R″ (where R′ and R″ are independently selected from the group consisting of hydrogen and lower alkyl);
• NR′C(O)R″ (where R′ and R″ are independently selected from the group consisting of hydrogen and lower alkyl);
• and
• —C(O)NR′R″ (where R′ and R″ are independently selected from the group consisting of hydrogen and lower alkyl);
• R4 is XR7, where X is —O—, —S—, —CH2—, —CH═CH—, —C≡C— or NR′ (where R′ is selected from the group consisting of hydrogen and lower alkyl) and where R7 is selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted C4-7 cycloalkenyl, —C(O)R, (where R is selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl), and —C(O)NR′R′(where R′ and R″ are independently selected from the group consisting of hydrogen and lower alkyl);
• and
• R5 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, —OR, —C(O)R, —C(O)OR, —OC(O)R, —C(O)NRR′, —NRC(O)R′, —NRR′, SR, SOR, SO2R, and SO2NRR′ (where R is selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl and R′ is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl).