Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

A compound having the following structure (I):

• or a stereoisomer, or pharmaceutically acceptable salt thereof,
• wherein:
• A is pyridyl, phenyl, quinolinyl, naphthyridinyl, thienopyrimidinyl, or 2-oxo-pyrimidinyl, wherein the pyridyl, phenyl, quinolinyl, thienopyrimidinyl or 2-oxo-pyrimidinyl is substituted with 0-5 R4;
• R1a is H, halogen, C1-4alkyl, C1-4alkoxy or trifluoromethyl;
• R1b and R1c are the same or different and are independently H, F, hydroxy, haloC1-4alkyl, —C1-6alkyl-(R5)p, —O—C1-6alkyl-(R5)p, —C1-6alkyl-O—C1-6alkyl-(R5)p, —NR7—C1-6alkyl-(R5)p, or —S(O)m—C1-6alkyl-(R5)p;
• R1d is F, Cl, methyl, CF3 or cyano;
• R2 is C1-4alkyl-(R5)p;
• R2a is phenyl substituted with 0-4 R3, heteroaryl substituted with 0-4 R3, C1-6alkyl substituted with 0-4 R3, aryl-C1-4alkyl substituted with 0-4 R3, or heteroaryl-C1-4alkyl substituted with 0-4 R3, wherein heteroaryl is an aromatic heterocycle ring of 5- to 10-members and having at least one heteroatom selected from N, O, and S, and containing at least 1 carbon atom, including both mono- and bicyclic ring systems;
• R3 at each occurrence is independently halogen, cyano, halo-C1-4alkyl, R5, —C1-6alkyl —(R5)p, —C1-6alkyl-O—C1-6alkyl-(R5)p, —NR7—C1-6alkyl-(R5)p, —S(O)m—C1-6alkyl-(R5)p, —O—C1-6alkyl-NR7—C1-6alkyl-(R5)p, heterocycle-(R5)p wherein the heterocycle is a 5- to 7-membered monocyclic ring or 7- to 14-membered polycyclic ring, containing from 1 to 4 heteroatoms independently selected from N, O, and S;
• R4 at each occurrence is independently halogen, C1-6alkyl, haloC1-4alkyl, C1-6alkoxy, hydroxy, cyano, thioC1-6alkyl, —C(O)NR7R8 or 5 member heteroaryl wherein the heteroaryl has at least one heteroatom selected from N, O, and S;
• R5 at each occurrence is independently H, hydroxy, —OC(O)—C1-6alkyl, —OC(O)O—C1-6alkyl, —OC(O)—C1-6alkyl-NR7R8, —COOR6, —C(O)NR7H8, —NR7C(O)NR7R8, —S(O)2NR9R9, —S(O)m-C1-4alkyl, —NR7R8, C1-6alkoxy, —O-heterocycle, or heterocycle wherein said heterocycle and said —O-heterocycle are substituted with 0-4 groups selected from halogen, C1-6alkyl, C1-4haloalkyl, hydroxy, oxo, =S, —NH2, —S(O)2C1-4alkyl and —COOH, and wherein the —O-heterocycle and the heterocycle are each independently a 5- to 7-membered monocyclic ring or 7- to 14-membered polycyclic ring, containing from 1 to 4 heteroatoms independently selected from N, O, and S;
• R6 at each occurrence is independently H, C1-4alkyl, C1-4alkyl-O—C(O)—C1-6alkyl, or C1-4alkyl-O—C(O)—O—C1-6alkyl;
• R7 at each occurrence is independently H, C1-4alkyl, hydroxy, or heterocycle where said heterocycle is substituted with 0-4 groups selected from halogen, C1-6alkyl, hydroxy, oxo, —NH2 and —COOH, and wherein the heterocycle is a 5- to 7-membered monocyclic ring or 7- to 14-membered polycyclic ring, containing from 1 to 4 heteroatoms independently selected from N, O, and S;
• R8 at each occurrence is independently H, C1-4alkyl, haloC1-4alkyl, —C(O)—C1-4alkyl, —C(O)-haloC1-4alkyl, —S(O)m-haloC1-4alkyl or —S(O)m—C1-4alkyl;
• R9 at each occurrence is independently H, C1-4alkyl, or —C(O)C1-4alkyl;
• m is 0-2;
• and
• p at each occurrence is independently 1-3.