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US 8,507,528 B2Granted
2-alkyl-indazole compounds for the treatment of certain cns-related disorders
AssigneeAziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
InventorsMaria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Lorenzo Polenzani
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Abstract
2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.
Claims8
A compound which is selected from the group consisting of
- N,2-dimethyl-N-{[1-(2-phenylethyl)piperidin-4-yl]methyl}-2H-indazole-3-carboxamide hydrochloride hemihydrate;
- N-({1-[2-(4-hydroxyphenyl)ethyl]piperidin-4-yl}methyl)-5-methoxy-2-methyl-2H-indazole-3-carboxamide;
- N-({1[2-(4-fluorophenyl)ethyl]piperidin-4-yl}methyl)-2-(2-methoxyethyl)-2-H-indazole-3-carboxamide hydrochloride;
- N-({1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl}methyl)-2-methyl-2H-indazole-3-carboxamide hydrochloride;
- 2-(2,4-difluorophenyl)-N-({1-[(2-methyl-2H-indazole-3-yl)carbonyl]piperidin-4-yl}methyl)ethanamine hydrochloride;
- and
- 2-(4-fluorophenyl)-N-({1-[(2-methyl-2H-indazol-3-yl)carbonyl)piperidin-4-yl}methyl]ethanamine hydrochloride,
- or a pharmaceutically acceptable salt of said compound.
5 more elements
Dependencies are inferred from the claim text.