US 8,507,527 B2 · Method for stabilizing anti-dementia drug

Abstract

The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

Claims2

Dependent claims

A method for stabilizing donepezil or a pharmaceutically acceptable salt thereof that is in contact with ethylcellulose, comprising adding a methacrylic acid-ethyl acrylate copolymer in a mixture comprising the donepezil or a pharmaceutically acceptable salt thereof, the ethylcellulose, and a water-soluble sugar or sugar alcohol during a mixing or granulation step and preparing a sustained-release matrix-type pharmaceutical composition comprising the donepezil uniformly distributed with the ethylcellulose and the methacrylic acid-ethyl acrylate copolymer, wherein the sustained-release matrix-type pharmaceutical composition comprises the ethylcellulose in an amount of 12% to 32% by weight, and the methacrylic acid-ethyl acrylate copolymer in an amount of 15.8% to 37% by weight.

Dependencies are inferred from the claim text.

Facts

Application

12/712,959Filed 25 Feb 2010 · division

Priority

JP 2004-37677027 Dec 2004

Published

US 2010/0152164 A117 Jun 2010

Granted

13 Aug 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 9/2054
Polysaccharides, e.g. alginate, gums; Cyclodextrin: cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61K 9/1635
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 9/1652
Organic macromolecular compounds: polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/2027
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates

Family

PCT/JP2005/024254Parent of this division · filed 27 Dec 2005

US 2010/0152164 A1Pre-grant publication · published 17 Jun 2010

Application11/793,722Parent of this division

US 2008/0213368 A1Published application

US 8,481,565 B2Related patent

US 8,507,527 B2This patent

From the US filing history. Foreign family members aren’t listed.

Method for stabilizing anti-dementia drug

Life of this patent

Method for stabilizing anti-dementia drug

Life of this patent

Abstract

Claims2