Heterocyclic derivatives

A heterocyclic derivative of formula I

• wherein
• R1 is C1-4alkyl, C0-4alkylC3-8cycloalkyl, or C0-4alkylZ1, said C1-4alkyl and C0-4alkylC3-8cycloalkyl being optionally substituted with one or more substituent independently selected from hydroxy, C1-4alkyl, C1-4alkyloxy, CN and halogen;
• Z1 is a 4-7 membered saturated ring containing a heteroatom selected from O, S and SO2;
• n is 1 or 2;
• each R2 and R3 is independently H or C1-4alkyl;
• Y is O or NR8;
• R4, R5, R6 and R7 are independently H or C1-4alkyl;
• or
• when Y is NR8, either R4 and R5, or R6 and R7, may together represent oxo;
• R8 is C1-4alkyl, C0-4alkylC3-8cycloalkyl, or C0-4alkylZ2, said C1-4alkyl and C0-4alkylC3-8cycloalkyl being optionally substituted with one or more substituent independently selected from hydroxy, C1-4alkyl, C1-4alkyloxy, oxo, CN and halogen;
• Z2 is a 4-7 membered saturated ring containing a heteroatom selected from O, S and SO2;
• X1-X7 are CR9;
• or one of X1 -X7 may be N;
• each R9 is independently selected from H, C1-4alkyl, C1-4alkyloxy, nitrile and halogen, said C1-4alkyl and C1-4alkyloxy being optionally substituted with one or more substituent independently selected from hydroxy and halogen;
• R10 and R11 are independently H or C1-4alkyl;
• or, when R10 is alkyl and X1 is CR9, R10 and R9 together with the atoms to which they are bonded may form a fused ring optionally comprising a heteroatomic moiety selected from O, S and SO2;
• or a pharmaceutically acceptable salt thereof.