Polysubstituted 2-aryl-6-phenylimidazo[1,2-A]pyridine derivatives, and preparation and therapeutic use thereof

A compound of formula (I):

• wherein:
• R1 represents a phenyl group or a naphthyl group, wherein these two groups are optionally substituted with one or more atoms or groups chosen, independently of one another, from the following atoms or groups:
• halogen, (C1-C10)alkyl, halo(C1-C10)alkyl, (C1-C10)alkoxy, halo(C1-C10)alkoxy, (C1-C10)thioalkyl, —S(O)(C1-C10)alkyl, —S(O)2(C1-C10-alkyl), hydroxyl, cyano, nitro, hydroxy(C1-C10)alkylene, NRaRb(C1-C10)alkylene, (C1-C10)alkoxy(C1-C10)alkylenoxy, NRaRb, CONRaRb, SO2NRaRb, NRcCORd, OC(O)NRaRb, OCO(C1-C10)alkyl, NRcC(O)ORe, NRcSO2Re, aryl(C1-C10)alkylene, monocyclic heteroaryl and aryl, wherein the monocyclic heteroaryl or aryl are optionally substituted with one or more substituents chosen from a halogen, and a (C1-C10) alkyl, halo (C1-C10)alkyl, (C1-C10)alkoxy, halo(C1-C10)alkoxy, NRaRb, hydroxyl, oxo, nitro, cyano or OCO(C1-C10)alkyl group;
• X represents from 1 to 4 substituents, which are identical to or different from one another, chosen from hydrogen, halogen, (C1-C10)alkyl, (C1-C10)alkoxy, NRaRb, cyano and nitro, wherein the (C1-C10)alkyl is optionally substituted with one or more groups chosen from a halogen, (C1-C10)alkoxy, halo(C1-C10)alkoxy, NRaRb or hydroxyl;
• R represents, at position 3, 5, 7 or 8 of the imidazo[1,2-a]pyridine, from 1 to 4 substituents, which are identical to or different from one another, chosen from a halogen, (C1-C10)alkyl, halo(C1-C10)alkyl and (C1-C10)alkoxy;
• R2 and R3 represent, independently of one another,
• a hydrogen atom;
• a (C1-C10)alkyl group, optionally substituted with an Rf group;
• or
• an aryl group, optionally substituted with one or more substituents chosen from a halogen, and a (C1-C10)alkyl, halo(C1-C10)alkyl, (C1-C10)alkoxy, halo(C1-C10)alkoxy, NRaRb, hydroxyl, nitro or cyano group;
• R2 and X can form, together with the carbon atoms which bear them, a carbon-based ring containing from 5 to 7 carbon atoms;
• R4 represents:
• a hydrogen atom;
• a (C1-C10)alkyl group, optionally substituted with an Rf group;
• or
• an aryl group, optionally substituted with one or more substituents chosen from a halogen, and a (C1-C10)alkyl, halo(C1-C10)alkyl, (C1-C10)alkoxy, halo(C1-C10)alkoxy, NRaRb, hydroxyl, nitro, cyano, (C1-C10)alkyl(CO)—, CONRaRb, NRcCORd, OC(O)NRaRb, OCO(C1-C10)alkyl, NRcC(O)ORe or aryl group, the aryl being optionally substituted with one or more substituents chosen from a halogen, and a (C1-C10)alkyl, halo(C1-C10)alkyl, (C1-C10)alkoxy, halo(C1-C10)alkoxy, NRaRb, hydroxyl, nitro or cyano group;
• Ra and Rb represent, independently of one another, a hydrogen atom or a (C1-C10)alkyl, aryl(C1-C10)alkylene or aryl group;
• or Ra and Rb form, together with the nitrogen atom which bears them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine or homopiperazine group, this group being optionally substituted with a (C1-C10)alkyl, aryl or aryl(C1-C10)alkylene group;
• Rc and Rd represent, independently of one another, a hydrogen atom or a (C1-C10)alkyl, aryl(C1-C10)alkylene or aryl group,
• or Rc and Rd together form a (C2-C5)alkylene group;
• Re represents a (C1-C10)alkyl, aryl(C1-C10)alkylene or aryl group,
• or Rc and Re together form a (C2-C5)alkylene group;
• and
• Rf represents a halogen atom, or a (C1-C10)alkoxy, halo(C1-C10)alkoxy, hydroxyl, cyano, NRaRb, C(O)NRaRb, NRcCORd, OC(O)NRaRb, OCO(C1-C10)alkyl, NRcCOORe, SO2NRaRb, NRcSO2Re, aryl(C1-C10)alkylene or aryl group, wherein the aryl is optionally substituted with one or more substituents chosen from a halogen, and a (C1-C10)alkyl, halo(C1-C10)alkyl, (C1-C10)alkoxy, halo(C1-C10)alkoxy, NRaRb, hydroxyl, nitro, cyano or OCO(C1-C10)alkyl group;
• or an acid addition salt thereof.