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US 8,507,516 B2Granted
Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
AssigneeBristol-Myers Squibb Company
InventorsIvar M. McDonald, Robert A. Mate, James H. Cook, II, Dalton King, Richard E. Olson, Nenghui Wang, Christiana I. Iwuagwu, F. Christopher Zusi, John E. Macor
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Abstract
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
Claims3
A compound of formula I, or a stereoisomer thereof,
- wherein
- R1 is selected from the group consisting of R1 is selected from the group consisting of benzothiazolyl, methoxybenzothiazolyl, thiazolopyridinyl, and isoquinoinyl;
- and
- n is 1;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.