Modulators of toll-like receptors

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• L1 is —NR8—, —O—, —S—, —N(R8)C(O)—, —S(O)2—, —S(O)—, or a covalent bond;
• R1 is H, alkyl, substituted alkyl, haloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylalkenyl, substituted carbocyclylalkenyl, carbocyclylalkynyl, substituted carbocyclylalkynyl, heterocyclylalkenyl, substituted heterocyclylalkenyl, heterocycloalkynyl, substituted heterocycloalkynyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroarylalkenyl, substituted heteroarylalkenyl, heteroarylalkynyl, substituted heteroarylalkynyl, carbocyclyl alkoxy, substituted carbocyclyl alkoxy, heterocyclyl alkoxy, substituted heterocyclyl alkoxy, aryl alkoxy, substituted aryl alkoxy, heteroaryl alkoxy, or substituted heteroaryl alkoxy;
• X2 is N;
• each non-hydrogen R5 may optionally connect to X1 to form an additional 5 to 8 membered carbocyclic or heterocyclic ring;
• each non-hydrogen R5 may optionally connect to D1 to form an additional 5 to 8 membered carbocyclic or heterocyclic ring;
• X1 is alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, carbocyclylene, substituted carbocyclylene, heterocyclylene, substituted heterocyclylene, —NR8—, —O—, —C(O)—, —S(O)—, —S(O)2—, or a covalent bond;
• D1 is aryl or heteroaryl;
• D2 is aryl or heteroaryl;
• each L2 is independently alkylene, substituted alkylene, or a covalent bond;
• each R2 is independently —NR6R7;
• m is 1 or 2;
• each R3 and R4 is independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogen, haloalkyl, haloalkoxy ═O, —OR8, —SR8, —NR9R10, ═NR8, ═NOR8, ═NNR8R9, —CN, —OCN, —SCN, —N═C═O, —NCS, —NO, —NO2, ═N2, —N3, —NR8C(═O)R9, —NR8C(═O)OR9, —NR8C(═O)NR9R10, —C(═O)NR9R10, —C(═O)OR8, —OC(═O)NR9R10, —OC(═O)OR8, —C(═O)R8, —S(═O)2OR8, —S(═O)2R8, —OS(═O)2OR8, —S(═O)2NR9R10, —S(═O)R8, —NR8S(═O)2R9, —NR8S(═O)2NR9R10, —NR8S(═O)2OR9, —OS(O)2NR9R10, —OP(═O)(OR8)2, —P(═O)(OR8)2, —P(O)(OR8)(R9), —P(O)R9R10, —OP(═O)R9R10, —C(═S)R8, —C(═S)OR8, —C(═O)SR8, —C(═S)SR8, —C(═S)NR9R10, —C(═NR8)NR9R10, or —NR8C(═NR8)NR9R10;
• each n is independently 0, 1, 2, 3, 4 or 5, depending on the size of the depicted ring D1 and D2, such that sufficient attachment points are present for each R3 and R4;
• R6 and R7 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, haloalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclylalkyl, substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylalkenyl, substituted carbocyclylalkenyl, carbocyclylalkynyl, substituted carbocyclylalkynyl, heterocyclylalkenyl, substituted heterocyclylalkenyl, heterocyclylalkynyl, substituted heteroalkynyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroarylalkenyl, substituted heteroarylalkenyl, heteroarylalkynyl, substituted heteroarylalkynyl, carbocycly alkoxy, substituted carbocyclyl alkoxy, heterocyclyl alkoxy, substituted heterocyclyl alkoxy, aryl alkoxy, substituted aryl alkoxy, heteroaryl alkoxy, or substituted heteroaryl alkoxy, —C(O)H, —C(O)R8, —S(O)R8, —S(O)2R8, —C(O)OR8, or —C(O)NR9R10, S(O)2NR9R10;
• or
• R6 and R7, taken together with the nitrogen to which they are both attached, form a substituted or unsubstituted 3 to 8 membered heterocycle, which may contain one or more additional heteroatoms selected from N, O, S, or P;
• or
• R7 taken together with L2, and the N to which they are both attached, forms a substituted or unsubstituted 3 to 8 membered heterocycle which may contain one or more additional heteroatoms selected from N, O, S, or P;
• or
• R7 taken together with D2, L2, and the N to which both R7 and L2 are attached forms a substituted or unsubstituted 5 to 15 membered heterocycle or heteroaryl which may contain one or more additional heteroatoms selected from N, O, S, or P;
• R8 is H, alkyl, substituted alkyl, haloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclylalkyl, substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylalkenyl, substituted carbocyclylalkenyl, carbocyclylalkynyl, substituted carbocyclylalkynyl, heterocyclylalkenyl, substituted heterocyclylalkenyl, heterocyclylalkynyl, substituted heteroalkynyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroarylalkenyl, substituted heteroarylalkenyl, heteroarylalkynyl, substituted heteroarylalkynyl, carbocyclyl alkoxy, substituted carbocyclyl alkoxy, heterocyclyl alkoxy, substituted heterocyclyl alkoxy, aryl alkoxy, substituted aryl alkoxy, heteroaryl alkoxy, or substituted heteroaryl alkoxy;
• and
• R9 and R10 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, haloalkyl, alkoxy, substituted alkoxy, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylalkenyl, substituted carbocyclylalkenyl, carbocyclylalkynyl, substituted carbocyclylalkynyl, heterocyclylalkenyl, substituted heterocyclylalkenyl, heterocyclylalkynyl, substituted heterocyclylalkynyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroarylalkenyl, substituted heteroarylalkenyl, heteroarylalkynyl, substituted heteroarylalkynyl, carbocyclyl alkoxy, substituted carbocyclyl alkoxy, heterocyclyl alkoxy, substituted heterocyclyl alkoxy, aryl alkoxy, substituted aryl alkoxy, heteroaryl alkoxy, or substituted heteroaryl alkoxy;
• or
• R9 and R10, taken together with the atom to which they are both attached, form a substituted or unsubstituted 3 to 8 membered heterocycle, which may contain one or more additional heteroatoms selected from N, O, S, or P.