Dihydropyrazolopyrimidinone derivative

A compound of Formula (I-I):

• or a pharmaceutically acceptable salt,
• wherein
• Q1 is a single bond, or a C1-C6 alkylene group, in which one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a carbonyl group, an imino group, a sulfinyl group or a sulfonyl group, and may be substituted with a halogen atom, a cyano group, a hydroxyl group, a C1-C6 alkyl group or a C1-C6 alkoxy group;
• R1a is a hydrogen atom, a hydroxyl group, a formyl group, a C1-C6 alkyl group, a di-C1-C6 alkylamino group, a hydroxy-C1-C6 alkyl group or a carboxyphenyl group, or a heterocyclic group, wherein said heterocyclic group means a monocyclic or bicyclic heterocyclic group formed of 3 to 7 carbon atoms in each ring and containing one or two nitrogen atoms, wherein said heterocyclic group may be aromatic or aliphatic, and which may have a substituent selected from the group consisting of a halogen atom, a hydroxyl group, an oxo group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6 alkyl group, a C1-C6 alkoxy-C1-C6 alkyl group, and a group represented by —R1b;
• R1b is a group represented by -Q2-A1 (R1c)R1d;
• Q2 is a single bond, or a C1-C6 alkylene group, in which one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a carbonyl group, an imino group, a sulfinyl group or a sulfonyl group, and may be substituted with a halogen atom, a cyano group, a hydroxyl group, an imino group, a C1-C6 alkyl group or a C1-C6 alkoxy group;
• A1 is a nitrogen atom, or a methine group which may be substituted with a hydroxyl group, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group;
• R1c and R1d are independently a hydrogen atom, a carboxyl group, a C1-C6 alkyl group, or a hydroxy-C1-C6 alkyl group, or together represent a C1-C6 alkylene group, in which one or two or more methylene groups constituting the C1-C6 alkylene group may be independently replaced with an oxygen atom, a sulfur atom, a sulfonyl group, a sulfonyl group, a carbonyl group, a vinylene group or a group represented by —N(R1e)-, and may be substituted with a hydroxyl group, a C1-C6 alkyl group or a hydroxy-C1-C6 alkyl group;
• R1e is a hydrogen atom, a formyl group, an acetyl group or a C1-C6 alkyl group;
• R1 is a hydrogen atom;
• a C1-C6 alkyl group which may have a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group, a C1-C6 alkoxy group, a C3-C6 cycloalkyl group, a C2-C7 alkanoyl group and a C1-C6 alkylsulfonyl group;
• or an aryl, aralkyl, or heteroaryl group which may have a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group, an amino group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkyl group and a hydroxy-C1-C6 alkyl group;
• R2 is an aryl, aralkyl or heteroaryl group, wherein said heteroaryl group means a 5 or 6 membered monocyclic heteroaryl group having one to three heteroatoms selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom, or a condensed-ring heteroaryl group formed by the condensation of the monocyclic heteroaryl group and the aryl group or by the condensation of the monocyclic heteroaryl groups, which may be the same or different, and which may have a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group, an amino group, a nitro group, a carbamoyl group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfonyl group, a halo-C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group and a C1-C6 alkoxy-C1-C6 alkyl group;
• and
• R4 and R5 are independently a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a hydroxy-C1-C6 alkylamino group, a carbamoyl group, or a hydroxy-C1-C6 alkylcarbamoyl group.