Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors

A compound of formula (I):

• Wherein the compound is a furo[2,3-d]pyrimidine compound
• X is N;
• Y is O, S, or NR2, in which R2 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl;
• A is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, cyano, nitro, OR3, OC(O)R3, C(O)R3, C(O)OR3, C(O)NR3R4, NR3R4, NHC(O)R3, NHC(O)NR3R4, NHC(S)R3, NHC(O)OR3, SO2R3, SO3R3, or SO2NR3R4, in which each of R3 and R4, independently, is H, alkyl, alkenyl, alkynyl, silyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl, R3 and R4 are optionally substituted, or R3 and R4, together with the nitrogen atoms to which they are bonded, are heterocycloalkyl, heterocycloalkenyl, or heteroaryl;
• B is aryl or heteroaryl;
• each of m and n, independently, is 0, 1, or 2;
• and
• ring C is
• or
• in which
• R″, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, nitro, cyano, ORa, C(O)ORa, C(O)NRaRb, NRbC(O)Ra, NHC(O)NRaRb, NRbC(S)Ra, NHSO2Ra, or NRaRb, in which each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl, Ra and Rb are optionally substituted, or Ra and Rb, together with the nitrogen atoms to which they are bonded, are heterocycloalkyl, heterocycloalkenyl, or heteroaryl,
• R′ is NRbC(O)Ra′, Ra′ being
• in which R6 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, C(O)Rc, C(O)ORc, C(O)NRcRd, or CH2NRcRd, in which each of Rc and Rd, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl, or Rc and Rd, together with the nitrogen atoms to which they are bonded, are heterocycloalkyl, heterocycloalkenyl, or heteroaryl, and R7 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl;
• Z is O, and W is CR5, in which R5 is alkenyl, alkynyl, aryl substituted with ORa, or NRbC(O)Ra, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, nitro, C(O)ORa, C(O)NRaRb, NRbC(O)Ra, NHC(O)NRaRb, NRbC(S)Ra, NHSO2Ra, or NRaRb.