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US 8,507,499 B2Granted
Substituted indole/indazole-pyrimidinyl compounds
AssigneeConfluence Life Sciences, Inc.
InventorsShaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas
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Abstract
The present disclosure provides indole/indazole-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein W, X, R1, R2, R3, R4, R5 and R6 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
Claims16
A compound, or a pharmaceutically acceptable salt of the compound, wherein the compound has the structure of Formula I:
- wherein:
- W and X are independently selected from the group consisting of CH and N;
- R1 is selected from the group consisting of cycloalkyl, aryl, heterocyclyl and heteroaryl;
- wherein the heterocyclyl and heteroaryl substituents may be optionally substituted with one or more substituents independently selected from the group consisting of cyano and alkyl;
- and wherein the cycloalkyl and aryl substituents may be optionally substituted with one or more substituents independently selected from the group consisting of halo, cyano, alkyl and alkoxy;
- R2 is selected from the group consisting of hydrogen, alkyl, alkoxy and halo;
- R3 and R4 are independently selected from the group consisting of hydrogen and alkyl;
- R5 is selected from the group consisting of alkyl and hydroxy;
- and
- R6 is selected from the group consisting of hydrogen and alkyl.
7 more elements
Dependencies are inferred from the claim text.