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US 8,507,497 B2Granted
Capped pyrazinoylguanidine sodium channel blockers
AssigneeParion Sciences, Inc.
InventorsMichael R. Johnson, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
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Abstract
Provided is a method of treating cystic fibrosis in which an effective amount of a compound represented by formula (I) is administered to a subject in need thereof: where the structural variables are as defined herein.
Claims5
A method of treating cystic fibrosis the method comprising administering to a subject in need thereof an effective amount of a compound represented by formula (I):
- wherein
- X is halogen;
- Y is —NH2;
- R1, R2 and R3 are each hydrogen;
- R4 is a group represented by the formula:
- n is 4;
- R5 is
- or a pharmaceutically acceptable salt thereof, and
- inclusive of all enantiomers, diastereomers, and racemic mixtures thereof.
6 more elements
Dependencies are inferred from the claim text.