Amide and amidine derivatives and uses thereof

A compound of formula (I):

• wherein
• L is —(CH2)n—, or —(CR38R39)m—X—(CR38R39)n— or —(CR38R39)m—X—(CR38R39)n—Y—;
• m is independently at each occurrence 0, 1, or 2;
• n is independently at each occurrence 0, 1, or 2;
• R1 is cycloalkyl or heterocycle selected from the group consisting of
• A is selected from the group consisting of alkyl, alkenyl, alkyl-NH-alkyl, alkylcarbonyl, alkylsulfonyl, alkylthio, aryl, arylalkyl, aryloxyalkyl, arylcarbonyl, arylsulfonyl, carboxyalkyl, carboxycycloalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, halogen, haloalkyl, heterocyclecarbonyl, heterocyclesulfonyl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, —NO2, —NR8—[C(R9R10)]p—C(O)—R11, —[C(R12R13)]q—CR12(OH)—R14, —[C(R12R13)]qC(O)—R14, —CR12═R13—C(O)—R14, —[C(R12R13)]qS(O)2—R14, —[C(R12R13)]qS(O)—R14, —[C(R12R13)]qS—R14, —O—[C(R12R13)]q—C(O)—R14, —OR15, —N(R16R17), NR8C(O)N(R19R20), —CO2R18, —C(O)—N(R19R20, —[C(R12R13)]p—C(O)—N(R19R20), —C(NH)NH2, —C(R21R22)—OR23, —C(R24R25)—N(R26R27), —C(═NOH)—N(H)2, —C(R28R29)—C(O)N(R30R31), —S(O)2—N(R32R33), —S(O)2—[C(R9R10]p—C(O)N(R32R33), and —C(R28R29)—S(O)2—N(R32R33), wherein
• p is 1, 2, 3, 4, 5 or 6,
• q is 0, 1, 2, 3, 4, 5 or 6,
• R8 is hydrogen, alkyl, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, aryloxy, hydroxy, alkoxy, cycloalkyloxy, heterocycleoxy, heterocycle, heterocyclealkyl, or heterocycleoxyalkyl,
• R9 and R10 are each independently hydrogen, alkyl, carboxy, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, heterocycle, heterocyclealkyl, or heterocycleoxyalkyl, or R9 and R10 together with the atom to which they are attached form cycloalkyl or heterocycle,
• R11 is hydrogen, alkyl, carboxy, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, aryloxy, arylalkyl, aryloxyalkyl, hydroxy, alkoxy, cycloalkyloxy, heterocycleoxy, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, or —N(R28R29),
• R12 and R13 are each independently hydrogen, alkyl, carboxy, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl or —N(R28R29), or R12 and R13 together with the atom to which they are attached form cycloalkyl or heterocycle,
• R14 is hydrogen, alkyl, carboxy, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxy, aryloxyalkyl, hydroxy, alkoxy, cycloalkyloxy, heterocycleoxy, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, or —N(R30R31),
• R15 is hydrogen, alkyl, alkylcarbonyl, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, haloalkyl, heterocycle, heterocyclealkyl, or heterocycleoxyalkyl,
• R16 and R17 are each independently hydrogen, alkyl, alkylcarbonyl, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, haloalkyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, alkylsulfonyl, cycloalkylsulfonyl, arylsulfonyl, formyl, or heterocyclesulfonyl, or R16 and R17 together with the atom to which they are attached form a heterocycle,
• R18 is hydrogen, alkyl, carboxyalkyl, cycloalkyl, carboxycycloalkyl, aryl, arylalkyl, aryloxyalkyl, heterocycle, heterocyclealkyl, or heterocycleoxyalkyl,
• R19 and R20 are each independently hydrogen, alkyl, carboxy, carboxyalkyl, cycloalkyl, cycloalkyloxy, carboxycycloalkyl, aryl, arylalkyl, aryloxy, aryloxyalkyl, heteroarylalkyl, heterocycle, heterocyclealkyl, heterocycleoxyalkyl, heterocycleoxy, hydroxy, alkoxy, alkylsulfonyl, cycloalkylsulfonyl, arylsulfonyl, heterocyclesulfonyl, or —[C(R12R13)q]C(O)R14, or R19 and R20 together with the atom to which they are attached form a heterocycle,
• R21, R22 and R23 are each independently hydrogen, alkyl, carboxyalkyl, carboxycycloalkyl, cycloalkyl, haloalkyl, aryl, heterocycle, or heterocyclealkyl,
• R24 and R25 are each independently hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, carboxyalkyl, carboxycycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, arylcarbonyl, arylsulfonyl, heterocyclecarbonyl, heterocyclesulfonyl, cycloalkyl, aryl, or heterocycle,
• R26 and R27 are each independently hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, carboxyalkyl, carboxycycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, arylcarbonyl, arylsulfonyl, heterocyclecarbonyl, heterocyclesulfonyl, hydroxy, alkoxy, cycloalkyloxy, aryloxy, heterocycleoxy, cycloalkyl, aryl, or heterocycle, or R26 and R27 together with the atom to which they are attached form a heterocycle,
• R28 and R29 are each independently at each occurrence hydrogen or alkyl,
• R30 and R31 are each independently at each occurrence hydrogen, alkyl, alkylcarbonyl, alkoxy, alkylsulfonyl, aryl, arylcarbonyl, aryloxy, arylsulfonyl, carboxyalkyl, carboxycycloalkyl, cycloalkyl, cycloalkylcarbonyl, cycloalkyloxy, cycloalkylsulfonyl, heteroaryl, heteroarylcarbonyl, heteroaryloxy, heteroarylsulfonyl, heterocycle, heterocyclecarbonyl, heterocycleoxy, heterocyclesulfonyl, or hydroxy, or R30 and R31 taken together with the atom to which they are attached form heteroaryl or heterocycle, and
• R32 and R33 are each independently at each occurrence selected from the group consisting of hydrogen, alkyl, alkoxy, alkylsulfonyl, aryl, arylalkyl, aryloxy, aryloxyalkyl, arylsulfonyl, alkyl-NH-alkyl, aryl-NH-alkyl, arylalkyl, haloalkyl, aryl-heterocycle, carboxy, carboxyalkyl, carboxycycloalkyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfonyl, heteroaryl, heteroarylalkyl, heteroaryloxyalkyl, heteroaryloxy, heteroarylsulfonyl, heterocycle, heterocycle-NH-alkyl, heterocyclealkyl, heterocycle-heterocycle, heterocycleoxyalkyl, heterocycleoxy, heterocyclesulfonyl, and hydroxy, or R32 and R33 taken together with the atom to which they are attached form a heterocycle;
• R2 is hydrogen, alkyl, or aryl;
• R3 and R4 are independently hydrogen, alkyl or cycloalkyl;
• R5 is hydrogen, alkyl, amino, aryl, cycloalkyl, heteroaryl, or heterocycle provided R5 is other than amino when L is —(CR38R39)m—X—(CR38R39)n—Y—;
• X is —O—, —S—, —S(O)—, —S(O)2—, —NR36—, or —CR36R37—;
• Y is O or NR40;
• R36 and R37 are independently at each occurrence hydrogen or alkyl;
• R38, R39 and R40 are independently at each occurrence hydrogen or alkyl;
• W is N—CN, N—OR6, N—R6, or S;
• and
• R6 is hydrogen or alkyl;
• or
• a pharmaceutically acceptable salt thereof.