Cyclic compound having pyrimidinylalkylthio group

A method of treating rheumatoid arthritis, age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, retinal vein occlusion, polyploid choroidal angiopathy, diabetic macular edema, psoriasis vulgaris or atherosclerosis comprising administering to a patient a therapeutically effective amount of a compound represented by the following formula (1) or a salt thereof:

• wherein the ring X represents
• which may have one or plural substituents selected from a halogen atom and an alkyl group;
• R1 and R2 may be the same or different and each represents a hydrogen atom, an alkyl group, an aryl group or an aromatic heterocyclic group;
• in the case where R1 or R2 is an alkyl group, the alkyl group may have one or plural substituents selected from the group consisting of an aryl group, a halogenoaryl group, an alkoxyaryl group and an alkylaryl group;
• in the case where R1 or R2 is an aryl group, the aryl group may have one or plural substituents selected from the group consisting of a halogen atom, a hydroxy group, an alkoxy group, a halogenoalkoxy group, an alkyl group, a halogenalkyl group, an aryl group, a halogenoaryl group, an alkoxyaryl group and an alkylaryl group;
• R1 and R2 may be combined together to form a nonaromatic heterocycle;
• R3 represents a hydrogen atom, a halogen atom, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, an amino group, an alkylamino group, a cycloalkylamino group, an arylamino group, an alkylcarbonylamino group, an arylcarbonylamino group, a mercapto group, an alkylthio group, an arylthio group, an alkylsulfinyl group or a nonaromatic heterocyclic group;
• in the case where R3 is an alkylamino group or an alkylcarbonylamino group, the alkyl moiety of which may have one or plural substituents selected from the group consisting of a hydroxy group, an alkoxy group, an aryl group, an amino group, an alkylamino group and a nonaromatic heterocyclic group;
• in the case where R3 is a cycloalkylamino group, the cycloalkyl moiety of which may have one or plural substituents selected from the group consisting of a hydroxy group and an alkoxy group;
• in the case where R3 is a nonaromatic heterocyclic group, the ring of which may have one or plural substituents selected from the group consisting of an alkyl group, a hydroxyalkyl group and an alkoxyalkyl group;
• A1 represents a sulfur atom, a sulfinyl group or a sulfonyl group;
• and
• A2 represents an alkylene group.