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US 8,507,476 B2Granted
Substituted arylamide diazepinopyrimidone derivatives
AssigneesSanofi, Mitsubishi Tanabe Pharma Corporation
InventorsAude Fayol, Alistair Lochead, Mourad Saady, Julien Vache, Philippe Yaiche
Life of this patent
Estimating the term…
Abstract
The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
Claims12
A compound of formula (I):
- wherein:
- Y represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom;
- z represents a bond, an oxygen atom, a nitrogen atom substituted by a hydrogen atom or a C1-3 alkyl group, a sulphur atom, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-2 perhalogenated alkyl group or an amino group;
- R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted by a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom;
- R2 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom;
- R3 represents a benzene ring or a naphthalene ring;
- the rings being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-2 perhalogenated alkoxy group, a C1-6 alkylsulfonyl group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group, a C2-12 dialkylamino group, an acetoxy group or an aminosulfonyl group, a 4-15 membered heterocyclic group, this group being optionally substituted by a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, or a C1-6 alkoxy group;
- R4 represents a hydrogen atom;
- a C1-6 alkyl group;
- a benzyl group, a phenethyl group, a benzyloxycarbonyl group, a C1-4 alkoxy carbonyl group, a benzene group, a naphthalene group, a 5,6,7,8-tetrahydronaphthalene group, a benzenesulfonyl group, a benzoyl group, a 4-15 membered heterocyclic group, the above-mentioned group being optionally substituted by 1 to 4 substituents selected from a halogen atom, a hydroxyl group, a C1-4 alkoxy group, a C1-2 perhalogenated alkyl group, a C1-6 alkyl group, a benzene group, a halogen atom, a C1-3 halogenated alkyl group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group or a C2-10 dialkylamino group;
- R5 represents a hydrogen atom or a C1-6 alkyl group;
- and
- n represents 0 to 3;
- or a salt thereof.
11 more elements
Dependencies are inferred from the claim text.