Biphenylcarboxamide derivatives as hedgehod pathway modulators
AssigneeIrm LLC
InventorsChristine Dierks, Markus Warmuth, Xu Wu
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Abstract
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
Claims10
A method of treating a hematological cancer comprising administering to a patient in need thereof a therapeutically effective amount of N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)biphenyl-3-carboxamide as shown by the below structure
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.