Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy
AssigneeEnzymotec Ltd.
InventorsDorit Plat, Dori Pelled, Avidor Shulman, Gal Ben-Dror
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Abstract
Described herein are various lipid mixtures, more particularly special mixtures of fatty acids esters, which may be phytosterol esters and/or glyceride esters. Said mixtures are evaluated in the context of their ability to, upon consumption, affect the levels of circulating LDL and HDL particles, and their therapeutic effect on conditions associated with lipid metabolism, such as atherosclerosis, diabetes, metabolic disorders, etc. Compositions, dietary nutrients, food supplements and nutraceuticals comprising the herein described mixtures are also described.
Claims21
An edible composition which comprises a mixture of esters of omega-3 long chain polyunsaturated fatty acids (omega-3 LC-PUFA), said mixture comprising (1) esters of omega-3 LC-PUFA with phytosterols or phytostanols or with both phytosterols and phytostanols and (2) esters of omega-3 LC-PUFA with glycerol, wherein the weight ratio of (2) to (1) in the mixture is from about 1.5:1 to about 1:9.
An orally administrable pharmaceutical or nutraceutical unit dosage capsule form comprising an edible composition which comprises a mixture of (1) esters of omega-3 LC-PUFA with glycerol and (2) esters of omega-3 LC-PUFA with phytosterols and phytostanols, wherein said unit dosage form contains from about 0.3 to about 0.8 gram omega-3 LC-PUFA, and wherein said unit dosage form provides at least 50% of the recommended daily intake (RDI) of phytosterols and 100% of the RDI of omega-3 LC-PUFA.
A method of treatment of metabolic syndrome and related conditions, said method comprising administering a therapeutically effective dose of an edible mixture of esters of LC-PUFA or compositions comprising thereof to a subject in need, wherein said mixture comprises esters of LC-PUFA with phytosterols and/or phytostanols and esters of LC-PUFA with glycerol, wherein the weight ratio of said LC-PUFA glycerol esters to their esters with phytosterol or phytostanol is from about 19:1 to about 1:9.
A method of reducing circulating atherogenic small-dense LDL particles, while maintaining a high proportion of HDL/LDL ratio, said method comprising administering a therapeutically effective dose of an edible mixture of esters of LC-PUFA or compositions comprising thereof to a subject in need, wherein said mixture comprises esters of LC-PUFA with phytosterols and/or phytostanols and esters of LC-PUFA with glycerol, wherein the weight ratio of said LC-PUFA glycerol esters to their esters with phytosterol or phytostanol is from about 19:1 to about 1:9.
A method of shifting the HDL profile in the direction of larger and less dense particles, particularly reducing the HDL3 subfraction while increasing the level of HDL2 subfraction, said method comprising administering a therapeutically effective dose of an edible mixture of esters of LC-PUFA or compositions comprising thereof to a subject in need, wherein said mixture comprises esters of LC-PUFA with phytosterols and/or phytostanols and esters of LC-PUFA with glycerol, wherein the weight ratio of said LC-PUFA glycerol esters to their esters with phytosterol or phytostanol is from about 19:1 to about 1:9.
Dependencies are inferred from the claim text.