Antiemetic-oral contraceptive combination
AssigneeLupin Limited
InventorsSheetal Kulkarni, Srirupa Das, Harshal Anil Jahagirdar, Satish Dalal, Shirish Kulkarni
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Abstract
The present invention relates to a method of reducing the incidence of nausea and vomiting associated with the administration of oral contraceptive formulation and a method of preparation of oral contraceptive formulation comprising progestin and/or estrogen and an antiemetic. The preferred oral contraceptive formulation comprises of levonorgestrel and an antiemetic.
Claims6
An oral pharmaceutical formulation comprising a combination of levonorgestrel and an antiemetic selected from ondansetron or meclizine within the same formulation, wherein levonorgestrel is contained in a delayed release portion comprising at least one delayed release agent selected from the group consisting of hydrophilic or hydrophobic polymers or mixtures thereof, and the antiemetic is contained in an immediate release portion comprising at least one pharmaceutically acceptable excipients, wherein at least 80% of antiemetic is released within 30 min in 0.1 N HCl and at least 80% of levonorgestrel is released within 30 min at pH 6.8, when the dissolution is carried out for 2 hours in 0.1 N HCl followed by pH 6.8 phosphate buffer using a USP Type I apparatus at 100 rpm.
Dependencies are inferred from the claim text.