C5a binding nucleic acids
AssigneeNOXXON Pharma AG
InventorsWerner Purschke, Florian Jarosch, Dirk Eulberg, Sven Klussmann, Klaus Buchner, Christian Maasch
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Abstract
The present invention is related to a nucleic acid, preferably binding to C5a, selected from the group comprising type A nucleic acids, type B nucleic acids, type C nucleic acids, type D nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ.ID.No. 73 to 79.
Claims67
A nucleic acid that binds C5a comprising in 5′→3′ direction, a first stretch, a second stretch Box A, a third stretch Box L, a fourth stretch Box B and a fifth stretch, wherein the first stretch and the fifth stretch optionally hybridize to form a double-stranded structure, the first stretch comprises four to eight nucleotides, the second stretch Box A comprises ASACGCCGVRYAGGWC (SEQ ID NO:30), the third stretch Box L comprises four to eleven nucleotides, the fourth stretch Box B comprises GWAGAAUSG (SEQ ID NO:32) and, the fifth stretch comprises four to eight nucleotides.
Dependencies are inferred from the claim text.