Methods and unit dose formulations for the inhalation administration of aminoglycoside antibiotics
AssigneeNovartis AG
InventorsRobert J Speirs, Barbara A Schaeffler, Peter B Challoner
Life of this patent
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Abstract
A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic, such as tobramycin, in a physiologically acceptable carrier in a time period of less than about 10 minutes. Unit dose devices for storage and delivery of the aminoglycoside antibiotic formulations are also provided.
Claims7
A method of treating a cystic fibrosis patient having an endobronchial infection comprising administering to the patient by inhalation using a piezoelectric oscillator inhalation device, a unit dose of 3.75 ml or less of a pharmaceutical formulation comprising from about 90 to about 120 mg/ml of tobramycin in a physiological carrier.
Dependencies are inferred from the claim text.