Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments
AssigneeBoehringer Ingelheim International GmbH
InventorsMatthias Eckhardt, Frank Himmelsbach, Tanja Butz, Martin Schuehle, Hans-Juergen Martin
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Abstract
The invention relates to a crystalline hydrate of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and to crystalline complexes between 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and a natural amino acid, to methods for the preparation thereof, as well as to uses thereof for preparing medicaments.
Claims17
A crystalline complex of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and proline, wherein said complex has an X-ray powder diffraction pattern that comprises peaks at 5.07, 7.28, 16.75, 17.55, 18.91, 20.34, 21.62, 23.21, and 28.75 degrees 2Θ (±0.05 degrees 2Θ), wherein said X-ray powder diffraction pattern is made using CuKα1 radiation.
A crystalline hydrate of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene, said crystalline hydrate having an X-ray powder diffraction pattern that comprises peaks at 4.53, 13.11, 17.16, 18.53, 19.10, 20.16, 20.86, 21.64 and 22.94 degrees 2Θ (±0.05 degrees 2Θ), wherein said X-ray powder diffraction pattern is made using CuKα1 radiation.
Dependencies are inferred from the claim text.