Anticancer agent
AssigneeThe Research Foundation for Microbial Diseases of Osaka University
InventorsEisuke Mekada, Shingo Miyamoto
Life of this patent
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Abstract
The present invention is an antineoplastic agent characterized by including at least one of taxol and taxol derivatives and a protein which is a mutant of diphtheria toxin, having an activity to inhibit a binding between HB-EGF and EGFR and substantially not having a toxicity of diphtheria toxin as active ingredients.
Claims10
An antineoplastic agent formulated for treating breast cancer characterized by combining (a) at least one of paclitaxel or irinotecan with (b) a protein which is a diphtheria toxin mutant having an activity to inhibit a binding between HB-EGF and EGFR and substantially not having toxicity of diphtheria toxin, wherein the paclitaxel is used in an amount equivalent a 0.875 to 1.375 mg dose per kilogram body weight, and the irinotecan is used in an amount equivalent to a 0.5 to 0.75 mg dose per kilogram body weight.
A method for treating breast cancer comprising administering (a) at least one of paclitaxel or irinotecan in combination with (b) a protein which is a diphtheria toxin mutant having an activity to inhibit a binding between HB-EGF and EGFR and substantially not having toxicity of diphtheria toxin wherein (a) and (b) are administered in amounts in which both independently have no sufficient anticancer action but the anticancer action is elicited by combining both (a) and (b).
A kit for treating breast cancer composed of (a) at least one of paclitaxel or irinotecan and (b) the protein which is diphtheria toxin mutant having the activity to inhibit the binding between HB-EGF and EGFR and substantially not having the toxicity of diphtheria toxin in amounts in which both independently have no sufficient anticancer action but the anticancer action is elicited by combining both (a) and (b).
An antineoplastic agent composition formulated for treating breast cancer composed of (a) at least one of paclitaxel or irinotecan and (b) a protein which is a diphtheria toxin mutant having an activity to inhibit a binding between HB-EGF and EGFR and substantially not having toxicity of diphtheria toxin in amounts in which both independently have no sufficient anticancer action but the anticancer is elicited by combining both (a) and (b).
Dependencies are inferred from the claim text.