Protein kinase C peptides for use in withdrawal
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDaria Mochly-Rosen, Joan J. Kendig, Sarah M. Sweitzer
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Abstract
A method for managing withdrawal from an addictive substance is described. The method involves administering one or more peptides having specific activity for the ε and/or γ isozyme of protein kinase C (PKC). The peptide(s) can be administered prior to, concurrent with, or subsequent to administration of the addictive substance. Also described is a kit having at least one container containing a peptide having isozyme-specific activity for εPKC or γPKC and instructions for use.
Claims17
A method for alleviating symptoms associated with withdrawal from an addiction to alcohol, comprising
- administering a peptide having isozyme-specifice inhibitory activity for γPKC,
- wherein said symptoms are selected from the group consisting of allodynia and hyperalgesia.
A method for alleviating symptoms associated with withdrawal from alcohol, comprising
- administering a conjugate comprising a peptide having the sequence of SEQ ID NO:2 and an N-terminal cysteine residue cross-linked via an N-terminal Cys-Cys bond to a carrier peptide comprising the sequence of SEQ ID NO:
- 3 and an N-terminal cysteine residue,
- wherein said symptoms are selected from the group consisting of allodynia and hyperalgesia.
A method for alleviating symptoms associated with withdrawal from alcohol, comprising
- administering a conjugate comprising a peptide having the sequence of SEQ ID NO:5 and an N-terminal cysteine residue cross-linked via an N-terminal Cys-Cys bond to a carrier peptide comprising the sequence of SEQ ID NO:3 and an N-terminal cysteine residue,
- wherein said symptoms are selected from the group consisting of allodynia and hyperalgesia.
Dependencies are inferred from the claim text.