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US 8,507,439 B2Granted
Neuroprotective and neurorestorative method and compositions
OwnerVictor E. Shashouainventor
Life of this patent
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Abstract
The invention relates to methods and products for preventing and treating neuronal cell death-associated diseases and/or conditions. The products and methods are useful for research and for clinical applications relating to neuronal cell-death associated diseases and/or conditions.
Claims10
A method for inhibiting neuronal cell death in a subject comprising:
- administering to a subject in need of such treatment a neuroprotective and/or neurorestorative peptide in an amount effective to inhibit neuronal cell death in the subject, wherein the neuroprotective and/or neurorestorative peptide is Y—ZN, wherein Y is a peptide moiety having an amino acid sequence set forth as SEQ ID NO:1, Z is a targeting compound moiety, and N is 0, 1, 2, or 3, wherein the targeting compound moiety is lipoic acid, wherein the subject has or is suspected of having neuronal cell death associated with Parkinson's disease (PD).
A method for treating a neuronal cell death-associated disease or condition comprising:
- administering to a subject in need of such treatment a neuroprotective and/or neurorestorative peptide in an amount effective to treat the disorder in the subject, wherein the neuroprotective and/or neurorestorative peptide is Y—ZN, wherein Y is a peptide moiety consisting of an amino acid sequence set forth as SEQ ID NO:1, Z is a targeting compound moiety, and N is 0, 1, 2, or 3, wherein the targeting compound moiety is lipoic acid, and wherein the neuronal cell death-associated disease is Parkinson's disease.
Dependencies are inferred from the claim text.