Apoptosis-modulating p53 protein therapy for vascular disorders and nanoparticles containing the same

A method of managing vascular inflammation in a patient following angioplasty comprising administering to said patient via a blood vessel, a nanoparticle formulation comprising a protein, at least one biodegradable polymer and an inert plasticizer, wherein said protein is selected from the group consisting of SEQ ID NO:

• 1, 2, 5-15 and 18 in a pharmaceutically acceptable carrier in an effective amount to manage vascular inflammation.

A method for inhibiting restenosis of a blood vessel comprising administering an effective amount of a p53 protein of SEQ ID NO:

• 1 containing nanoparticle formulation for sustained release of an effective amount of p53 protein, said formulation comprising p53 protein, at least one bio-degradable polymer, and an inert plasticizer via said blood vessel to a subject in need of treatment, thereby inhibiting restenosis in said blood vessel.

A method of managing vascular inflammation in a patient following angioplasty comprising administering to said patient via a blood vessel, a p53 protein of SEQ ID NO:1 containing nanoparticle formulation for sustained release of p53 protein, said formulation comprising p53 protein, at least one bio-degradable polymer, and an inert plasticizer in an effective amount to manage vascular inflammation at the site of injury.