Peptide modulators of angiogenesis and use thereof
AssigneeThe Johns Hopkins University
InventorsAleksander S. Popel, Emmanouil D. Karagiannis
Life of this patent
Estimating the term…
Abstract
Compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators are described. As discussed in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
Claims9
An isolated peptide or analog thereof consisting of a sequence having at least 85% amino acid sequence identity to Transmembrane protein 45A LLRSSLILLQGSWF (SEQ ID NO:
- 2296) wherein the peptide reduces blood vessel formation in a cell, tissue or organ.
Dependencies are inferred from the claim text.