Sugar chain added GLP-1 peptide

An oligosaccharide chain added glucagon-like peptide-1 (GLP-1) peptide having GLP-1 activity, wherein one amino acid is substituted with an oligosaccharide chain added amino acid, wherein said oligosaccharide chain is not an O-linked oligosaccharide chain, in

• (a) GLP-1;
• or
• (b) a GLP-1 analog;
• wherein said oligosaccharide chain is represented by the following formula:
• wherein:
• R1 and R2 are the same or different and each represents
• and
• Ac represents an acetyl group.

An oligosaccharide chain added glucagon-like peptide-1 (GLP-1) peptide having GLP-1 activity, wherein two amino acids are each substituted with oligosaccharide chain added amino acids, wherein said oligosaccharide chains are not O-linked oligosaccharide chains, in GLP, wherein:

• at least one of said oligosaccharide chain added amino acids is oligosaccharide chain added Asn;
• in at least one of said oligosaccharide chain added amino acids, the oligosaccharide chain is linked to the amino acid without a linker;
• at least one of said oligosaccharide chains consists of four or more sugars;
• and
• at least one of said oligosaccharide chains is selected from the group consisting of disialo, monosialo, asialo, diGlcNAc and dimannose oligosaccharide chains.

An oligosaccharide chain added glucagon-like peptide-1 (GLP-1) peptide having GLP-1 activity, wherein two amino acids are each substituted with oligosaccharide chain added amino acids, wherein said oligosaccharide chains are not O-linked oligosaccharide chains, in GLP, wherein said oligosaccharide chains are represented by the following formula:

• wherein:
• R1 and R2 are the same or different and each represents
• and
• Ac represents an acetyl group.