Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMarkus H. Frank, Mohamed H. Sayegh
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Abstract
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
Claims6
A population of isolated 7p P-glycoprotein positive stem cells, consisting of stem cells that have been isolated using an antibody directed against 7p P-glycoprotein, wherein the stem cells are muscle progenitor stem cells, neuroprogenitor cells, or hematopoietic stem cells.
Dependencies are inferred from the claim text.