Calcium channel proteins and uses thereof
AssigneeCalcimedica, Inc.
InventorsKenneth A. Stauderman, Jack Roos, Gonul Velicelebi
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Abstract
Described herein are compositions and uses thereof related to Ca2+ release-activated Ca2+ (CRAC) channel activity. Also described herein CRAC channel modulators for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
Claims7
An isolated mammalian cell comprising (a) a stromal interacting molecule (STIM) polypeptide or a polypeptide at least 95% identical to the amino acid sequence of the STIM polypeptide, and (b) an Orai polypeptide or a polypeptide at least 95% identical to the amino acid sequence of the Orai polypeptide, wherein one or both polypeptides are over-expressed.
An isolated mammalian cell comprising (a) a stromal interacting molecule (STIM) polypeptide or a polypeptide at least 95% identical to the amino acid sequence of the STIM polypeptide, (b) an Orai polypeptide or a polypeptide at least 95% identical to the amino acid sequence of the Orai polypeptide, wherein one or both polypeptides are recombinant.
Dependencies are inferred from the claim text.