Method of treating inflammation with statins
AssigneeMUSC Foundation for Research Development
InventorInderjit Singh
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Abstract
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.
Claims17
A method of treating inflammation in cells of a subject that does not have an elevated cholesterol level, to reduce the risk of cardiovascular disease or stroke, the method comprising:
- a) determining the level of inflammation in a subject, or in cells of the subject, which subject does not have an elevated cholesterol level, by testing for an indicator of inflammation;
- b) administering to cells of those subjects determined in step a) to have elevated level of inflammation by virtue of such testing, an amount of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that is effective to reduce said inflammation and reduce the risk of cardiovascular disease or stroke in said subject.
Dependencies are inferred from the claim text.