Tuberculosis diagnostic test
AssigneeIsis Innovation Limited
InventorsAjit Lalvani, Ansar Pathan
Life of this patent
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Abstract
A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided.
Claims18
A method of in vitro diagnosis of Mycobacterium tuberculosis infection in a host, comprising
- (a) keeping a population of T cells isolated from said host in contact with a peptide panel comprising one or more epitopes contained within peptide SEQ ID NO:
- 1, and
- (b) detecting a recognition response by the T cells to the peptide panel.
A method of in vitro diagnosis of Mycobacterium tuberculosis infection in a host, comprising
- (a) keeping a population of T cells isolated from said host in contact with a peptide panel comprising peptide SEQ ID NO:
- 1, peptide SEQ ID NO:
- 2, peptide SEQ ID NO:
- 3, peptide SEQ ID NO:
- 4, peptide SEQ ID NO:
- 5, peptide SEQ ID NO:
- 6, peptide SEQ ID NO:
- 7, and peptide SEQ ID NO:
- 8;
- and
- (b) detecting a recognition response by the T cells to the peptide panel.
Dependencies are inferred from the claim text.